Thrombocytopenia and Giant Platelets



 

This is a condition where there is a reduction of the platelets (thrombocytes) from the norm. Platelets play an important role in blood clotting and so the decrease can mean increased bleeding. Thromocytopenia can be of a secondary nature which means the result of another condition, eg. Infection, tumour or drug reaction, or of a primary nature where not other causative factor is found and thought to be an auto-immune problem. Some symptoms might include nosebleeds, bruising on the skin or lips, blood in the stool or urine and lethargy or weakness. Treatment generally include steroids and in more serious cases transfusions.

An Aranel (UK) puppy


The Cavalier King Charles Spaniel, however, have giant sized platelets which function normally. When a blood sample is analysed the number of platelets are counted using an autoanalyser. This machine recognises the cell by the size and when using an autoanalyser the platelet count is low in the Cavalier, possibly leading to a misdiagnoses of thrombocytopenia. All blood samples from Cavaliers should be examined by an experienced clinical pathologist under a microscope and the platelets counted manually.